A lot of Americans are keeping an important, possibly deadly secret. The National Institute of Mental Health reports that approximately 18.8 million American adults have a depressive disorder. The disease is not discriminating, seeping into all age, race, gender, and socioeconomic groups. Depression stalls careers, strains relationships, and sometimes ends lives.

So if this many people are living with the disease, why the silence? This program explores the disease's complex terrain, offering a comprehensive and timely examination of this devastating disorder.

Following the film, broadcast journalist Jane Pauley will host a 30-minute roundtable discussion in which nationally acclaimed experts will offer advice on recognizing and treating depression.

Wednesday, 5/21/08 from 9-10 p.m. ET